Travogen® [Isoconazole]
Bayer Pharma AG
828 Items
2019-09-19
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Clinical Pharmacology
Travogen - antifungal, antibacterial.
Pharmacodynamics
Isoconazole is a synthetic imidazole derivative. It has a local antifungal and antibacterial effect. Fungistatically, with increasing concentration - fungicidal. Suppresses the synthesis of ergosterol and changes the composition of the membrane of the microbial cell. Active against dermatophytesTrichophyton spp., Microsporum spp., Epidermophyton spp., mold, yeast and yeast-like fungi (Candida spp., Pityrosporum orbiculare), andCorynebacterium minutissimum - causative agent of erythrasma and gram-positive bacteriaStaphylococcus spp., Streptococcus spp.
Pharmacokinetics
When applied to the skin, systemic absorption is negligible.
Indications
Fungal lesions of the skin, incl. secondarily infected:
- mycoses of the feet and smooth skin, incl. with localization in the folds and the area of the external genital organs;
- microsporia, trichophytosis, rubrofitia;
- athlete's disease;
- candidiasis;
- multi-colored (scaly) versicolor;
- erythrasma
Composition
100 g of cream contains:
Active substance: isoconazole nitrate 1 g;
Excipients:polysorbate 60; sorbitan stearate; cetyl stearyl alcohol; liquid paraffin; white petrolatum; purified water.
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Dosage and Administration
Topically Adults and children from 1 month old. Travogen is applied with a thin layer to the affected skin and lightly rubbed once a day. The course of treatment is usually 2-3 weeks, with the localization of mycoses in the folds - up to 4 weeks. A longer course of treatment is also possible. To prevent relapse, treatment should continue for 2 weeks after resolution of clinical manifestations.
Adverse reactions
Travogen is usually well tolerated, even when applied to sensitive skin. Rarely, irritation (burning sensation and itching, erythema) may develop, and skin allergic reactions are extremely rare.
Contraindications
Increased sensitivity to components of Travogen.
Pregnancy and Lactation
The use of Travogen during pregnancy is possible in cases where the potential benefit to the mother outweighs the risk to the fetus. It is not established whether isoconazole penetrates into breast milk, so the drug should not be applied to the breast glands before feeding. If necessary, use the drug to resolve the issue with the doctor about stopping breastfeeding.
Special instructions
The drug is intended for external use only.
When the first symptoms, indicating hypersensitivity or irritation, the drug should be canceled.
Avoid contact with eyes. In case of accidental contact with the drug in the eyes, rinse thoroughly with warm water.
If you experience side effects that are not listed in the instructions, you must inform them to your doctor.
If there is no effect during treatment, you should consult a doctor.
Pediatric use
Treatment by Travogen of children from 1 month to 2 years is carried out under the supervision of a physician.
- Brand name: Travogen
- Active ingredient: Isoconazole
- Dosage form: Cream for external use
- Manufacturer: Bayer Pharma AG
- Country of Origin: Germany
Studies and clinical trials of Isoconazole (Click to expand)
- In vitroactivity of cloconazole, sulconazole, butoconazole, isoconazole, fenticonazole, and five other antifungal agents against clinical isolates ofCandida albicansandCandidaspp.
- Superficial Dermatomycoses Worldwide: Multinational Treatment Experience with a Combination of Isoconazole Nitrate and Diflucortolone Valerate
- Treatment of candidal intertrigo with a topical combination of isoconazole nitrate and diflucortolone valerate
- Tinea incognito due to Trichophyton rubrum responsive to topical therapy with isoconazole plus corticosteroid cream
- Successful treatment of tinea pedis with a topical agent containing isoconazole nitrate and diflucortolone valerate
- Tinea corporis treated with a combined topical therapy containing isoconazole and a corticosteroid
- Tinea cruris treated with a combined topical therapy containing isoconazole and a corticosteroid
- The effective use of isoconazole nitrate and diflucortolone valerate cream in the treatment of inguino-femoral skin fold mycosis
- Step-wise treatment of athlete’s foot (tinea pedis) using isoconazole combined with a corticosteroid followed by isoconazole alone
- Successful therapy of tinea cruris with topical isoconazole in combination with a corticosteroid
- Contact dermatitis to isoconazole nitrate
- Perkutane Resorption von Isoconazol beim Menschen: Percutaneous Absorption of Isoconazole in Humans
- Persistence of Isoconazole in Vaginal Secretion after Single Application : Verweildauer von Isoconazol im Vaginalsekret nach einmaliger Applikation
- Glycosidic activities of Candida albicans after action of vegetable latex saps (natural antifungals) and isoconazole (synthetic antifungal) : Glykosid-Aktivitäten an Candida albicans nach Einwirkung natürlicher Antimyzetika pflanzlicher Milchsäfte und des synthetischen Antimyzetikums Isoconazol
- Isoconazole nitrate versus clotrimazole in foot and nail infections due to Hendersonula toruloidea, Scytalidium hyalinum and dermatophytes : Isoconazolnitrat versus Clotrimazol bei Fu- und Nagelinfektionen durch Hendersonula toruloidea, Scytalidium hyalinum und Dermatophyten
- Isoconazole nitrate in the treatment of tropical dermatomycoses : Isoconazolnitrat-Behandlung tropischer Dermatomykosen
- Non-invasive analysis of penetration and storage of Isoconazole nitrate in the stratum corneum and the hair follicles
- Study of the forced degradation of isoconazole nitrate in bulk drug and cream formulations
- New copper(II) complexes with isoconazole: Synthesis, structures and biological properties
- Pustular allergic contact dermatitis to isoconazole nitrate
- Diflucortolone/isoconazole
- Fixed drug eruption caused by ornidazole and fluconazole but not isoconazole, itraconazole, ketoconazole and metronidazole
- SINGLE DOSE THERAPY FOR VAGINAL CANDIDIASIS WITH ISOCONAZOLE
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