Clindamycin

Brand Vertex

In stock 1309 Items

Available since: 2019-09-19

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Clinical Pharmacology

Bacteriostatic antibiotic from the group of lincosamides, has a broad spectrum of activity, binds to the 50S subunit of the ribosomal membrane and inhibits protein synthesis in the microbial cell. In respect of a number of gram-positive cocci possible bactericidal action.
Active against Staphylococcus spp. (including Staphylococcus epidermidis, producing and not producing penicillinase), Streptococcus spp. (excluding Enterococcus faecalis), Streptococcus pneumoniae, Corynebacterium diphtheriae, Mycoplasma spp., anaerobic and microaerophilic gram-positive cocci (including Peptococcus spp. and Peptostreptococcus spp.), Clostridium perfringens, chrystrophycene, chrystrophys, sest. (including Bacteroides fragilis and Prevotella melaninogenica), Fusobacterium spp., Propionibacterium spp., Eubacterium spp., and Actinomyces Israelii. Most strains of Clostridium perfringens are sensitive to clindamycin, but other types of Clostridium spp. (including Clostridium sporogenes, Clostridium tertium) are resistant to its action, therefore, for infections caused by Clostridium spp., the definition of an antibiogram is recommended.
There is cross-resistance between clindamycin and lincomycin.

Indications

vaginitis caused by microorganisms sensitive to drugs.

Composition

clindamycin

Clindamycin is marketed under different brands and generic names, and comes in different dosage forms:

Brand name	Manufacturer	Country	Dosage form
Clindamycin	Vertex	Russia	cream
Zercalin®	Jadran-Galensky Laboratories ao	Croatia	bottle
Clindovit	Akrikhin	Russia	gel
Dalacin	Pfizer	USA	suppositories
Dalacin	Pfizer	USA	cream
Dalacin	Pfizer	USA	gel

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Dosage and Administration

Intravaginal: vaginal cream administered in a single dose - 100 mg of clindamycin (1 applicator) at night, the course of treatment - 3-7 days.

Adverse reactions

Allergic reactions (including skin rash, urticaria).
Irritation at the site of application, cervicitis, vaginitis, development of superinfection (fungal vaginitis).

Contraindications

Hypersensitivity, pregnancy I trimester (for vaginal cream).

Drug interactions

Drug interaction

Pregnancy and Lactation

During pregnancy, it is possible if the expected effect of therapy outweighs the potential risk to the fetus (adequate and well-controlled studies in pregnant women have not been performed, clindamycin passes through the placenta and can be concentrated in the fetal liver, but no complications have been registered in humans). As a result of research, it has not been established whether treatment of bacterial vaginosis reduces the risk of adverse pregnancy outcomes, such as premature rupture of membranes, premature onset of labor or premature delivery.

Caution should be exercised when used during breastfeeding (it is not known whether clindamycin penetrates into breast milk after external and intravaginal use, but is found in breast milk after oral or parenteral administration).