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Bacteriostatic antibiotic from the group of lincosamides, has a broad spectrum of activity, binds to the 50S subunit of the ribosomal membrane and inhibits protein synthesis in the microbial cell. In respect of a number of gram-positive cocci possible bactericidal action.
Active against Staphylococcus spp. (including Staphylococcus epidermidis, producing and not producing penicillinase), Streptococcus spp. (excluding Enterococcus faecalis), Streptococcus pneumoniae, Corynebacterium diphtheriae, Mycoplasma spp., anaerobic and microaerophilic gram-positive cocci (including Peptococcus spp. and Peptostreptococcus spp.), Clostridium perfringens, chrystrophycene, chrystrophys, sest. (including Bacteroides fragilis and Prevotella melaninogenica), Fusobacterium spp., Propionibacterium spp., Eubacterium spp., and Actinomyces Israelii. Most strains of Clostridium perfringens are sensitive to clindamycin, but other types of Clostridium spp. (including Clostridium sporogenes, Clostridium tertium) are resistant to its action, therefore, for infections caused by Clostridium spp., the definition of an antibiogram is recommended.
There is cross-resistance between clindamycin and lincomycin.
vaginitis caused by microorganisms sensitive to drugs.
Clindamycin is marketed under different brands and generic names, and comes in different dosage forms:
|Brand name||Manufacturer||Country||Dosage form|
|Zercalin®||Jadran-Galensky Laboratories ao||Croatia||bottle|
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Dosage and Administration
Intravaginal: vaginal cream administered in a single dose - 100 mg of clindamycin (1 applicator) at night, the course of treatment - 3-7 days.
Allergic reactions (including skin rash, urticaria).
Irritation at the site of application, cervicitis, vaginitis, development of superinfection (fungal vaginitis).
Hypersensitivity, pregnancy I trimester (for vaginal cream).
Drug interactionsDrug interaction
Pregnancy and Lactation
During pregnancy, it is possible if the expected effect of therapy outweighs the potential risk to the fetus (adequate and well-controlled studies in pregnant women have not been performed, clindamycin passes through the placenta and can be concentrated in the fetal liver, but no complications have been registered in humans). As a result of research, it has not been established whether treatment of bacterial vaginosis reduces the risk of adverse pregnancy outcomes, such as premature rupture of membranes, premature onset of labor or premature delivery.
Caution should be exercised when used during breastfeeding (it is not known whether clindamycin penetrates into breast milk after external and intravaginal use, but is found in breast milk after oral or parenteral administration).
Vaginal cream is not recommended for use simultaneously with other intravaginal drugs.
Symptoms: increased severity of side effects.
Treatment: symptomatic and supportive. Not indicated by hemodialysis and peritoneal dialysis.
- Brand name: Clindamycin
- Active ingredient: Clindamycin
- Dosage form: Vaginal cream
- Manufacturer: Vertex
- Country of Origin: Russia
- Comparison of ampicillin/sulbactam versus clindamycin in the prevention of infection in patients undergoing head and neck surgery
- Transdermal absorption of clindamycin and tretinoin from topically applied anti-acne formulations in man
- Effect of intravaginal clindamycin cream on pregnancy outcome and on abnormal vaginal microbial flora of pregnant women
- Absorption kinetics of topical clindamycin preparations
- Evaluation of gender in the oral pharmacokinetics of clindamycin in humans
- Ultrasensitive assay of clindamycin in medicine and bio-fluids with chemiluminescence detection
- Fatal pseudomembranous enterocolitis following clindamycin therapy
- One-dose antibiotic prophylaxis against wound infection after appendicectomy: A randomized trial of clindamycin, cefazolin sodium and a placebo
- Clindamycin in the treatment of soft tissue infections: A review of 15 019 patients
- Simple method for the assay of clindamycin in human plasma by reversed-phase high-performance liquid chromatography with UV detector
- ChemInform Abstract: Antibiotic Inhibitors of the Peptidyl Transferase Center. Part 1. Clindamycin as a Composite Analogue of the Transfer RNA Fragments L-Pro-Met and the D-Ribosyl Ring of Adenosine.
- Resonance Rayleigh Scattering Spectrum of Palladium(II)- Clindamycin-Halofluorescein Systems and Their Analytical Applications
- Investigation of enantiomeric separation of basic drugs by capillary electrophoresis using clindamycin phosphate as a novel chiral selector
- Gentamicin-loaded bone cement with clindamycin or fusidic acid added: Biofilm formation and antibiotic release
- Treatment of contaminated bone defects with clindamycin-reconstituted bone xenograft-composites
- Determination of clindamycin in animal plasma by high-performance liquid chromatography combined with electrospray ionization mass spectrometry
- Comparison of cortical bone and serum concentrations of clindamycin achievable by direct local infusion and intravenous administration
- Antimicrobial efficacy of gentamicin-loaded acrylic bone cements with fusidic acid or clindamycin added
- Aqueous stability of clindamycin
- Hydrolysis of lincomycin-2-phosphate and clindamycin-2-phosphate
- Absorption of clindamycin from the buccal cavity
- Transfer of clindamycin and 1′-demethyl-4′-depropyl-4′-pentylelindamycin by the cannulated-everted rat gut
- Clindamycin dose-bioavailability relationships
- Serum protein binding of erythromycin, lincomycin, and clindamycin