Mupirocin

Brand Belupo

In stock 1745 Items

Available since: 2019-09-19

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Clinical Pharmacology

Pharmacological action: Mupirocin - bacteriostatic broad-spectrum antibiotic for local use. Suppresses the synthesis of bacterial proteins by reversible and specific binding to isoleucyl transport RNA synthetase.
Effects on pathogens of skin infections: Staphylococcus aureus (including strains resistant to methicillin), Staphylococcus epidermidis, Staphylococcus saprophyticus and Streptococcus pyogenes (including coagulase negative strains).
It is not cross-resistant with chloramphenicol, erythromycin, fusidic acid, gentamicin, lincomycin, methicillin, neomycin, streptomycin, tetracycline.
Pharmacokinetics: Mupirocin practically does not penetrate intact skin. In case of absorption through damaged skin, it is metabolized to a microbiologically inactive metabolite, monium acid, and is rapidly excreted from the body by the kidneys.

Indications

Primary and secondary infections of the skin caused by microorganisms sensitive to mupirocin, including:
- primary skin infections - pyoderma (streptoderma, staphyloderma): impetigo, sycosis, folliculitis, furunculosis (including furuncles of the external auditory canal and auricle), ecthyma;
- secondary infections - infected eczema, infected atopic, contact and allergic dermatitis, infected injuries (abrasions, cuts, scratches, insect bites), trophic ulcers, minor (not requiring hospitalization) wounds and burns;
- prevention of bacterial lesions and their complications arising from small wounds, cuts, pressure sores.

Composition

1 g:
- Mupirocin 20 mg
excipients: macrogol 400 - 587 mg; macrogol 3350 - 393 mg

Mupirocin is marketed under different brands and generic names, and comes in different dosage forms:

Brand name	Manufacturer	Country	Dosage form
Bonderm	Belupo	Croatia	ointment
Supirocin	Glenmark	India	ointment
Supirocin B	Glenmark	India	ointment

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Dosage and Administration

Topically.
A small amount of Bonderm ointment is applied to the affected surface of the skin 2-3 times a day. The course of treatment is up to 10 days, depending on the severity of the lesion. In the absence of a clinical effect after 5 days of treatment, it is recommended to revise the diagnosis and further treatment tactics taking into account the dynamics of clinical indicators.
Bonderm® ointment can be applied using an aseptic dressing or applied under an occlusive dressing.
Children and elderly patients. Restrictions are not required.
Liver dysfunction. No correction required.
Impaired renal function. See “With Care.”

Adverse reactions

Bonderm® ointment is well tolerated. Very rarely, burning, itching and dryness at the site of application. Allergic skin reactions (swelling at the site of application, rash) on mupirocin or ointment base were rarely observed. When using the ointment in isolated cases, generalized allergic reactions were reported.

Contraindications

- hypersensitivity to any component of the drug Bonderm;
- children's age up to 3 years.
With care: a renal failure (see. "Special Instructions").

Drug interactions

Concurrent use with other topical preparations should be avoided, as this may reduce the antimicrobial activity or stability of mupirocin in the ointment.

Pregnancy and Lactation

Currently, there is insufficient data on the use of mupirocin in pregnancy, so the use of the drug is possible if the expected benefit exceeds the possible risk of complications.
Removal of the drug in breast milk is unlikely, however, the use of the drug in nursing mothers is possible if the expected benefit outweighs the risk of complications.

Special instructions

Macrogol, which is part of Bonderm ointment for external use, is absorbed from open wounds and damaged skin and excreted from the body by the kidneys, so patients with severe chronic renal failure should use the drug with caution over large areas of skin.
Avoid contact with eyes and mucous membranes. If the ointment gets into the eyes and mucous membranes, it is recommended to rinse them thoroughly with water until all the ointment remains are completely removed.
In rare cases of allergic reactions or significant irritation of the skin when using Bonderm ointment, treatment should be stopped, the affected area should be washed with water to remove residual ointment and an alternative antibiotic therapy should be prescribed.
Influence on the ability to drive a car or perform work that requires increased speed of physical and mental reactions. Adverse effects on the ability to drive vehicles and mechanisms was not observed.