Genistein
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Clinical Pharmacology
Component Properties
Isoflavones (genistein)
Isoflavones are bioflavonoids. These are substances of plant origin or their synthetic analogues, which show effects similar to the action of estrogen of the female body, in conditions of lack of production of their own estrogens.
Isoflavones have antioxidant, anti-inflammatory and antipyretic properties, as well as inhibit the formation of thrombin and platelet aggregation, thereby, contribute to the prevention of cardiovascular diseases.
The use of isoflavones reduces the frequency of hot flashes, sweating, headaches and other symptoms observed during menopause.
Positive effect on body function
The menopause period is characterized by varying hormones and a decrease in the production of estrogen by the ovaries in women.
During the period of menopause, there are often "hot flashes" - sensations of sudden heat in the head, face and upper half of the body, accompanied by excessive sweating. Tides last from a few seconds to a few minutes.
There may also be sleep disturbances, weight gain, mood swings, nervousness and irritability, headache, weakness, fatigue, changes in blood pressure, vaginal dryness and a decrease in sexual activity.
Menoril has a positive effect on various manifestations of menopause and menopause symptoms:
- Reduces the frequency of "tides";
- Contributes to the normalization of blood pressure;
- Reduces feelings of weakness, fatigue;
- Reduces headaches associated with "flushes";
- Improves mood, increases sexual activity.
Composition
one capsule contains:
main components: GeniVida TG (genistein at least 95%) - 31.6 mg;
auxiliary components: lactose monohydrate - 311.4 mg; calcium stearate - 5.25 mg; colloidal silicon dioxide (aerosil) - 1.75 mg.
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Dosage and Administration
Adults take one capsule 2 times a day with meals. Duration of reception is 1 month. Before use, it is recommended to consult a doctor.
Individual intolerance to the components of dietary supplements; pregnancy and lactation.
Studies and clinical trials of Genistein (Click to expand)
- Genistein inhibits the growth of human-patient BPH and prostate cancer in histoculture
- Genistein inhibits growth of B16 melanoma cells in vivo and in vitro and promotes differentiation in vitro
- Inhibition of human bladder cancer cell motility by genistein is dependent on epidermal growth factor receptor but not p21ras gene expression
- Attenuation by genistein of sodium-chloride-enhanced gastric carcinogenesis induced by N-methyl-N′-nitro-N-nitrosoguanidine in Wistar rats
- Genistein attenuates peritoneal metastasis of azoxymethane-induced intestinal adenocarcinomas in Wistar rats
- A microbore high performance liquid chromatography/electrospray ionization mass spectrometry method for the determination of the phytoestrogens genistein and daidzein in comminuted baby foods and soya flour
- On-line sample preparation using restricted-access media in the analysis of the soy isoflavones, genistein and daidzein, in rat serum using liquid chromatography electrospray mass spectrometry
- Genistein inhibits proliferation similarly in estrogen receptor-positive and negative human breast carcinoma cell lines characterized by P21WAF1/CIP1 induction, G2/M arrest, and apoptosis
- Inhibition of UV irradiation–induced oxidative stress and apoptotic biochemical changes in human epidermal carcinoma A431 cells by genistein
- Supercritical Carbon Dioxide Extraction of Daidzein and Genistein from Soybean Products
- Detrimental effect of cancer preventive phytochemicals silymarin, genistein and epigallocatechin 3-gallate on epigenetic events in human prostate carcinoma DU145 cells
- Genistein blocks breast cancer cells in the G2M phase of the cell cycle
- Low-dose genistein induces cyclin-dependent kinase inhibitors and G1 cell-cycle arrest in human prostate cancer cells
- Synthesis of D4-6′-hydroxy-O-demethylangolensin, a deuterium labelled metabolite of genistein
- Genistein in Sanfilippo disease: A randomized controlled crossover trial
- Preparation and characterization of genistein containing poly(ethylene glycol) microparticles
- Transcellular transport of genistein, a soybean-derived isoflavone, across human colon carcinoma cell line (Caco-2)
- Effects of estrogens and the phytoestrogen genistein on adipogenesis and lipogenesis in males and females
- NTP-CERHR expert panel report on the reproductive and developmental toxicity of genistein
- Scavenging of reactive oxygen species by the plant phenols genistein and oleuropein
- Synthesis and Cytotoxic Evaluation of a Series of Genistein Derivatives
- Synthesis and Cytotoxic Evaluation of Novel 7-O-Modified Genistein Derivatives
- ChemInform Abstract: Genistein and Fluorinated Analogues Suppress Agonist-Induced Airway Smooth Muscle Contraction.
- ChemInform Abstract: Formation of Polyhydroxylated Isoflavones from the Isoflavones Genistein and Biochanin A by Bacteria Isolated from Tempe.