Buy Monurol® [Fosfomycin]
  • Buy Monurol® [Fosfomycin]
  • Buy Monurol® granules 3 g sachets 2 pcs
  • Buy Monurol® granules 3 g sachets 2 pcs

Monurol® [Fosfomycin]

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Clinical Pharmacology

The broad-spectrum antibiotic, a derivative of phosphonic acid, has a bactericidal effect, the mechanism of which is associated with the suppression of the first stage of the synthesis of the bacterial cell wall. It is a structural analogue of phosphoenol pyruvate, enters into a competitive interaction with the enzyme N-acetyl-glucosamino-3-o-enolpyruvil transferase. As a result, specific, selective and irreversible inhibition of this enzyme occurs, which ensures the absence of cross-resistance with other classes of antibiotics and the possibility of synergism with other antibiotics (synergism with amoxicillin, cephalexin, pimemidic acid is noted in vitro).

Active in vitro against most gram-positive microorganisms: Enterococcus spp., Enterococcus faecalis, Staphylococcus aureus, Staphylococcus saprophyticus, Staphylococcus spp .; Gram-negative microorganisms: Essherichia coli, Citrobacter spp., Enterobacter spp., Klebsiella spp., Klebsiella pneumoniae, Morganella morganii, Proteus mirabilis, Pseudomonas spp., Serratia spp. In vitro fosfomycin reduces the adhesion of a number of bacteria on the urinary tract epithelium.


- acute bacterial cystitis;

- acute attacks of recurrent bacterial cystitis;

- bacterial non-specific urethritis;

- Asymptomatic massive bacteriuria in pregnant women;

- postoperative urinary tract infections;

- prevention of urinary tract infections during surgery and transurethral diagnostic studies.


Fosfomycin trometamol 5.631 g, incl. fosfomycin 3g

Auxiliary substances: tangerine flavoring, orange flavoring, saccharin, sucrose.

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Monurol® [Fosfomycin]

Dosage and Administration

Adults take the drug 3 g 1 time / day. The course of treatment is 1 day. If necessary (for severe or recurrent infections, the elderly), it is possible to re-take the drug in a dose of 3 g after 24 hours.

In order to prevent infection of the urinary tract during surgery, transurethral diagnostic procedures, the drug is taken at a dose of 3 g 3 hours before the intervention and 3 g 24 hours after the first dose.

Children over the age of 5 years, the drug is prescribed in a dose of 2 g only once.

In appointing the drug to patients with renal insufficiency, reduce the dose and increase the interval between doses.

Before taking the granules dissolved in 1/3 cup of water. The drug is taken 1 time per day on an empty stomach 2 hours before or after meals (preferably before bedtime), after emptying the bladder.

Adverse reactions

Co side of the digestive system: nausea, heartburn, diarrhea.

Other: skin rash, allergic reactions.


- severe renal failure (QC

- children's age is younger than 5 years;

- Hypersensitivity to the drug.

Drug interactions

With simultaneous use with metoclopramide, a decrease in the concentration of fosfomycin in the serum and in the urine is possible (this combination is not recommended).

Pregnancy and Lactation

Use of the drug during pregnancy and lactation is possible only if the intended benefit of therapy for the mother outweighs the potential risk of teratogenic action.

Special instructions

In appointing Monurol® to patients with diabetes mellitus, it should be borne in mind that 1 bag containing 2 g of fosfomycin contains 2.1 g of sucrose, and 1 bag containing 3 g of fosfomycin contains 2. 213 g of sucrose.


The risk of overdose is minimal.

Treatment: forced diuresis.

  • Brand name: Montelukast
  • Active ingredient: Fosfomycin
  • Dosage form: Granules for the preparation of oral solution.
  • Manufacturer: Zambon
  • Country of Origin: Italy

Studies and clinical trials of Fosfomycin (Click to expand)

  1. Comparative X-ray analysis of the un-liganded fosfomycin-target MurA
  2. On the Transformation of (S)-2-Hydroxypropylphosphonic Acid into Fosfomycin in Streptomyces fradiae—A Unique Method of Epoxide Ring Formation
  3. Einbau von L-[Methyl-2H3]methionin und 2-[Hydroxy-18O]hydroxyethylphosphonsäure in Fosfomycin in Streptomyces fradiae — ein ungewöhnlicher Methyltransfer
  4. Incorporation of L-[Methyl-2H3]methionine and 2-[Hydroxy-18O]hydroxyethylphosphonic Acid into Fosfomycin in Streptomyces fradiae—An Unusual Methyl Transfer
  5. Studies on the Biodegradation of Fosfomycin: Synthesis of 13C-Labeled Intermediates, Feeding Experiments with Rhizobium huakuii PMY1, and Isolation of Labeled Amino Acids from Cell Mass by HPLC
  6. ChemInform Abstract: Antibiotic Fosfomycin; It is Small but Has Potential for the Future
  7. A Short Synthesis of a Novel Nucleoside Analogue of Fosfomycin.
  8. Studies on Organophosphorus Compounds. Part 128. Enzymatic Synthesis of Phosphocarnitine, Phosphogabob and Fosfomycin.
  9. ChemInform Abstract: An Efficient, One-Pot Synthesis of Fosfomycin Dialkyl Esters from (R)-2-Tosyloxypropanal.
  10. Capillary electrophoresis analysis of fosfomycin in biological fluids for clinical pharmacokinetic studies
  11. Biosynthesis of Natural Products with a PC Bond, X. Incorporation of D-[1-2H1]Glucose into 2-Aminoethylphosphonic Acid in Tetrahymena thermophila and into Fosfomycin in Streptomyces fradiae. — the Stereochemical Course of a Phosphoenolpyruvate Mutase-Catalyzed Reaction
  12. Biosynthese von Naturstoffen mit einer PC-Bindung, IX. Synthese und Einbau von (S)- und (R)-2-Hydroxy-[2-2H1]ethylphosphonsäure in Fosfomycin durch Streptomyces fradiae
  13. Synthesis of tritium-abeled fosfomycin
  14. Effects of vancomycin, daptomycin, fosfomycin, tigecycline, and ceftriaxone on Staphylococcus epidermidis biofilms
  15. Quantum mechanical calculations useful for determining the mechanism of action of fosfomycin
  16. Self-consistent field-molecular orbital (SCF-MO) calculations and nuclear magnetic resonance measurements for fosfomycin and related compounds
  17. Flow Injection Spectrophotometric Determination of the Antibiotic Fosfomycin in Pharmaceutical Products and Urine Samples after On-line Thermal-Induced Digestion
  18. Application of ion chromatography with indirect spectrophotometric detection to the sensitive determination of alkylphosphonic acids and fosfomycin
  19. Thermogravimetric analysis of calcium and disodium fosfomycin. Analytical application for purity control
  20. Fosfomycin determination in serum by capillary zone electrophoresis with indirect ultraviolet detection
  21. Determination of fosfomycin in biological fluids by capillary electrophoresis
  22. Phosphonic drugs: Experimental and theoretical spectroscopic studies of fosfomycin
  23. Silicon directed asymmetric synthesis of (1R, 2S)-(−)-(1,2-Epoxypropyl)phosphonic acid (fosfomycin) from (S)-lactaldehyde
  24. On the conversion of structural analogues of (S)-2-hydroxypropylphosphonic acid to epoxides by the final enzyme of fosfomycin biosynthesis in S. fradiae

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