Sodium picosulphate

Brand Boehringer Ingelheim

In stock 1221 Items

Available since: 2019-09-19

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Clinical Pharmacology

Guttalax has a laxative effect. It reduces the absorption of electrolytes and water, increases intestinal peristalsis. The active form of the drug is formed by hydrolysis under the influence of intestinal microorganisms and directly excites the receptors of the intestinal wall, accelerating the promotion of intestinal contents. The laxative effect develops 10-12 hours after administration.

Indications

Atonic constipation.
Regulation of the chair (hemorrhoids, proctitis, anus fractures).
Preparing for surgery, instrumental and radiological studies.

Composition

1 ml of drops contains:

Active substance: sodium picosulfate 7.5 mg;

Excipients: sodium methyl paraoxybenzoate; sorbitol 70%; hydrochloric acid; purified water.

Sodium picosulphate is marketed under different brands and generic names, and comes in different dosage forms:

Brand name	Manufacturer	Country	Dosage form
Guttalax	Boehringer Ingelheim	Austria	drops
Picodinar			solution
Guttalax	Boehringer Ingelheim	Austria	pills
Slabicap	Synthesis AKOMP	Russia	drops
Laxigal	Teva	Israel	drops
Slabilen	Veropharm	Russia	drops

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Dosage and Administration

Inside The following dosing regimen is recommended: Adults and children over 10 years old: 10-20 drops (5-10 mg) per day. 4 Children 4-10 years old: 5-10 drops (2.5-5 mg) per day. It is recommended to start with the lowest dose. In order to achieve regular stools, the dose may be increased to the maximum recommended. Do not exceed the maximum recommended daily dose. The recommended dose for children under 4 years old is 0.25 mg / kg body weight per day. This corresponds to 1 drop of the drug (0.5 mg of sodium picosulfate) per 2 kg of body weight per day. To obtain a laxative effect in the morning hours, you should take the drug the night before. During application, the bottle should be held vertically. The drug does not necessarily dissolve in liquid.

Adverse reactions

With short-term use of the drug side effects are rarely observed.

Possible side effects are classified by frequency as follows:

very often (≥ 1/10),

often (≥ 1/100, <1/10),

infrequently (≥ 1/1000, <1/100),

rarely (≥ 1/10000, <1/1000),

very rarely (<1/10000),

frequency is unknown (currently there are no data on the prevalence of adverse reactions).

With prolonged use of the drug in significantly higher doses, the following disorders are possible: on the part of the skin and subcutaneous tissues

frequency is unknown: skin rash, urticaria, itching;

from the metabolism and nutrition

frequency is unknown: increased excretion of potassium, sodium and other electrolytes, the development of dehydration is possible;

from the gastrointestinal tract

very often: diarrhea; often: dyspeptic phenomena, cramps and abdominal pain, flatulence;

infrequently: vomiting, nausea;

frequency is unknown: pain in the stomach and anus, increased intestinal motility, which pass with a decrease in the dose of the drug;

by the immune system

frequency is unknown: allergic reactions, angioedema, allergic dermatitis;

nervous system

infrequently: dizziness;

frequency is unknown: headache, fatigue, drowsiness, convulsions, fainting.

Contraindications

- intestinal obstruction or obstructive bowel disease;

- acute diseases of the abdominal organs or severe abdominal pain, which may be accompanied by nausea, vomiting, fever, including appendicitis;

- acute inflammatory bowel disease; - Hypersensitivity to sodium picosulfate or other components of the drug;

- severe dehydration;

- fructose intolerance;

- pregnancy (I term).

With caution Use with caution in older people, with hypokalemia, increasing the concentration of magnesium in the blood, patients with asthenia.

The use of the drug in patients with severe renal failure only under medical supervision.

Use during pregnancy and during breastfeeding: There are no reliable and well-controlled studies in pregnant women. Long experience of use did not reveal the negative effect of the drug on pregnancy. Taking the drug in the first trimester of pregnancy is contraindicated. In the II and III trimesters of pregnancy (as with the use of other laxatives), the drug can be taken only by prescription. The active metabolite and its glucuronides are not excreted in breast milk. Thus, the drug can be used during breastfeeding.

Drug interactions

Diuretics and glucocorticosteroids increase the risk of electrolyte imbalance (hypokalemia) when taking high doses of the drug. Disruption of electrolyte balance may increase sensitivity to cardiac glycosides. The combined use of the drug and antibiotics can reduce the affectionate effect of the drug.

Special instructions

Like other laxatives, Sodium picosulphate should not be taken daily for more than 10 days without consulting a doctor. If necessary, daily intake of laxatives should find out the cause of constipation. Prolonged use of laxatives can lead to disruption of water and electrolyte balance and hypokalemia, as well as cause "addiction" and constipation due to the effect of "rebound." Sodium picosulphate should be taken under medical supervision in conditions associated with impaired water and electrolyte balance (for example, in severe renal impairment). Cases of dizziness and / or fainting have been reported, which coincided in time with the use of sodium picosulphate. An analysis of the cases showed that these conditions are associated with fainting during bowel movements (or fainting caused by stress during defecation) or are associated with a vasovagal reaction to abdominal pain, which may be due to constipation, and is not necessarily associated with taking the drug. Sodium picosulphate is effective in eliminating constipation in cancer patients receiving large doses of opioids. Studies on the effect of the drug on fertility were not conducted. In the course of preclinical studies, no teratogenic effects on reproduction were identified. The drug contains sorbitol, so it is not recommended to take it to patients with a rare hereditary fructose intolerance. The drug has no taste, so it can be added to children in food. Children should take the drug only on prescription. Impact on the ability to drive vehicles and mechanisms Special clinical studies of the effect of the drug on the ability to drive vehicles and work with other mechanisms have not been conducted. Despite this, patients should be warned about the possibility of development due to vasovagal reaction (in particular abdominal spasm) of such adverse reactions as dizziness and / or syncope. In the case of abdominal spasm, the patient should avoid such potentially dangerous activities as driving or working with other mechanisms.