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Xeomin acts selectively on peripheral cholinergic nerve endings, inhibiting the release of acetylcholine. The introduction into the cholinergic nerve endings occurs in three stages: the binding of the molecule to the external components of the membrane, the internalization of the toxin by endocytosis and the translocation of the endopeptidase domain of the toxin from the endosome to the cytosol. In the cytosol, the endopeptidase domain of the toxin molecule selectively cleaves SNAP-25, an important protein component of the mechanism controlling the membrane movement of the exo-vesicles, thus stopping the release of acetylcholine. The end effect is relaxation of the injected muscle.
The action of the drug begins within four to seven days after the injection. The effect of each procedure usually lasts three to four months, although it can last much longer or less.
Blepharospasm, idiopathic cervical dystonia (spastic torticollis) of predominantly rotational form, hand spasticity after stroke, hyperkinetic folds (mimic wrinkles) of the face.
1 bottle contains:
active substance: botulinum toxin type A 50 U, sucrose 4.7 mg, human serum albumin 1.0 mg.
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