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Aethoxysklerol has a venosclerotic, local anesthetic effect. Damages the vascular endothelium, causing protein denaturation, stimulates the rapid formation of a blood clot and its organization within 7 days. Aethoxysklerol reduces the excitability of nerve endings and the conductivity of pain impulse, ensuring painless sclerotherapy.
Sclerosis of varicose veins and telangiectasias, hemorrhoids; obliteration or parietal sclerosis of varicose veins of the esophagus and stomach in acute bleeding from esophageal varices and condition after it, complete portal vein thrombosis, intrahepatic block shuntrombosis, etc.
1 ml solution for injection contains polydocanol 30 mg.
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Dosage and Administration
Aethoxysklerol is administered strictly IV with a horizontal or elevated 30-45 ° leg position.
The total dose of polidocanol during sclerosis of varicose veins and hemorrhoids should not exceed 2 mg / kg body weight per day. For a patient with a weight of 70 kg, it is possible, therefore, to inject up to 140 mg of polidocanol (28 ml of a 0.5% solution of Aethoxysklerol, 14 ml of a 1% solution of Aethoxysklerol, 4.6 ml of a 3% solution of ethoxsclerol).
When hardening the varicose veins of the extremities: hyperpigmentation of the skin at the site of administration of Aethoxysklerol.
When sclerosing hemorrhoids: transient pain.
When hardening the esophagus and stomach varicose veins: necrosis, ulceration and esophageal stenosis, exudation into the pleural cavity, dysphagia, fever, anaphylactic shock.
Absolute: hypersensitivity, shock, bed rest, diseases caused by arterial occlusion of III-IV degree, chronic arterial insufficiency, acute inflammatory diseases in the field of hardening.
Relative: superficial and deep (especially) vein thrombosis, edema, symptoms of diabetic microangiopathy, acute and chronic heart diseases (endocarditis, myocarditis), feverish conditions, diseases caused by arterial occlusion of the II degree (for cosmetic indications), bronchial asthma.
Strengthens arrhythmogenic activity of local anesthetics and drugs for general anesthesia.
Pregnancy and Lactation
Contraindicated in the first trimester of pregnancy and after 36 weeks; breastfeeding after administration of Ethoxyscleolol is recommended to stop for 2-3 days.
CHF in the compensation phase and stable hypertension are not contraindications for sclerotherapy.
Sclerosing drugs should not be administered in / a, because this can lead to severe necrosis and forced amputation. In case of accidental IVjecting, inject a 5-10 ml of 1-2% solution of lidocaine or mepivacaine, 500 IU of heparin into a needle left in the artery; wrap the limb with cotton and put it down; hospitalize the patient to the vascular surgery department.
The introduction of sclerosing drugs into the veins of the facial part of the skull is carried out only under strict indications.
Symptoms: with paravasal administration - necrosis.
Treatment: administration of 0.5-2 ml of 1% procaine solution or 5-20 ml of 0.9% NaCl solution in combination with hyaluronidase.
- Brand name: Aetoxisclerol
- Active ingredient: Polidocanol
- Dosage form: Injection.
- Manufacturer: Kreisler Hemishche Fabrik
- Country of Origin: Germany
Studies and clinical trials of Polidocanol (Click to expand)
- Sonographically guided percutaneous sclerosis using 1% polidocanol in the treatment of vascular malformations
- Efficacy of Percutaneous US-Guided Polidocanol Sclerotherapy: Long-Term Follow-up of 100 Patients with Polycystic Liver Disease
- A sclerosant with astringent properties developed in China for oesophageal varices: Comparison with ethanolamine oleate and polidocanol
- Comparison of polidocanol and tetracycline in the sclerotherapy of testicular hydrocele and epididymal cyst
- Injection of polidocanol foam (PF) in varicose veins as a trigger for attacks of migraine with visual aura
- Sclerotherapy for Leg Telangiectasia—A Blinded Comparative Trial of Polidocanol and Hypertonic Saline
- Reversible Cardiac Arrest After Polidocanol Sclerotherapy of Peripheral Venous Malformation
- Multicystic recurrence of hydrocele testis after sclerosing with polidocanol followed by spontaneous cure
- Sclerotherapy of hydroceles with polidocanol
- Endoscopic closure of bronchopleural fistula after pneumonectomy by submucosal injection of polidocanol
- Langzeitergebnisse nach perkutaner Sklerosierung von Nierenzysten mit Polidocanol
- Long-term results after percutaneous sclerotherapy of kidney cysts with polidocanol
- Sclerosing polidocanol injections in chronic painful tennis elbow-promising results in a pilot study
- Sclerosing polidocanol injections in mid-portion Achilles tendinosis: remaining good clinical results and decreased tendon thickness at 2-year follow-up
- Sclerosing polidocanol injections to treat chronic painful shoulder impingement syndrome-results of a two-centre collaborative pilot study
- Treatment of midportion Achilles tendinosis: similar clinical results with US and CD-guided surgery outside the tendon and sclerosing polidocanol injections
- Neovascularisation in de Quervain’s disease of the wrist: novel combined therapy using sclerosing therapy with polidocanol and eccentric training of the forearms and wrists—a pilot report
- Sclerosing injections to treat midportion Achilles tendinosis: a randomised controlled study evaluating two different concentrations of Polidocanol
- Sclerosing polidocanol injections in Achilles tendinopathy in high level athletes
- Does the dosage matter in sclerosing polidocanol injections in Achilles tendinopathy?
- Reply to the letter from Dr. Karsten Knobloch regarding our article “Sclerosing injections to treat midportion Achilles tendinosis: a randomized controlled study evaluating two different concentrations of polidocanol”
- Hepatotoxic effects of polidocanol in a model of autologously perfused porcine livers
- Percutaneous Treatment of Congenital Splenic Cysts: Drainage and Sclerotherapy with Polidocanol
- Foam Sclerotherapy Using Polidocanol (Aethoxysklerol) for Preoperative Portal Vein Embolization in 16 Patients