Buy Lidocaine ampoules 10%, 2 ml, 10 pcs
  • Buy Lidocaine ampoules 10%, 2 ml, 10 pcs

Lidocaine

Moskhimpharmpreparaty
1714 Items
2019-09-19
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Clinical Pharmacology

Lidocaine It is a local anesthetic that also has antiarrhythmic activity.

Assign with all types of local anesthesia: infiltration, conductive and superficial. The anesthetic effect of lidocaine hydrochloride is 2-6 times stronger than novocaine.

The drug blocks the flow of sodium ions in myocardial cells and suppresses the automaticity of ectopic foci, acts faster and longer. Reduces the effective refractory period, significantly reduces the amplitude of the action potential of myocardial cells.

It has a weak effect on the electrophysiological properties of the atria and therefore is ineffective in the atrial forms of cardiac arrhythmias. The drug has little effect on hemodynamics, only in large doses inhibits myocardial contractility and intracardiac conduction.

Indications

Local anesthesia: superficial, infiltration, conduction, epidural, spinal, intralgamentary with surgery, painful manipulations, endoscopic and instrumental studies.

In dental practice, oral surgery:

  • opening of superficial abscesses;
  • removal of mobile falling out teeth;
  • removal of bone fragments and suturing the wounds of the mucous membranes;
  • anesthesia of the gums for fixing the crown or bridge;
  • manual or instrumental removal (or excision) of the enlarged papilla of the tongue;
  • to reduce or suppress the increased pharyngeal reflex in preparation for X-ray examination;
  • anesthesia for excision of superficial benign tumors of the oral mucosa;
  • in children, for frenuloectomy and opening of cysts of the salivary glands.

In ENT practice:

  • before electrocoagulation (in the treatment of nasal bleeding), septectomy and resection of nasal polyps;
  • before tonsillectomy to reduce the pharyngeal reflex and anesthetize the injection site;
  • as an additional anesthetic before opening the peritonsular abscess or before the puncture of the maxillary sinus;
  • anesthesia before washing the sinuses.

With endoscopy and instrumental examinations:

  • anesthesia before the introduction through the nose or mouth of various probes (duodenal probe, before the fractional food test);
  • anesthesia before rectoscopy and in case of catheter replacement.

In obstetrics and gynecology:

  • perineal anesthesia for the treatment and / or episiotomy;
  • anesthesia of the surgical field in vaginal or cervical surgery;
  • anesthesia for excision and in the treatment of rupture of the hymen;
  • anesthesia with suturing abscesses.

In dermatology:

  • anesthesia of mucous membranes with minor surgical interventions.

Composition

1 ml contains lidocaine hydrochloride 100 mg.

Lidocaine is marketed under different brands and generic names, and comes in different dosage forms:

Brand nameManufacturerCountryDosage form
Lidocaine Moskhimpharmpreparaty Russia ampoules
Lidocaine Moscow Endocrine Plant Russia eye drops
Lidocaine-SOLOpharm Grotex Ltd Russia solution
Lidocaine PFK Obnovlenie Russia solution
Lidocaine Biochemist Saransk Russia Other
Lidocaine Vial Vial Russia spray
Lidocaine Biogen Russia spray
Lidocaine Egis Hungary spray
Versatis Grünentalh GmbH Germany patch
Lidocaine Pharmstandard Russia spray
Lidocaine BPMP Belarus ampoules
Lidocaine Synthesis AKOMP Russia eye drops
Lidocaine Egis Hungary solution

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Lidocaine

Dosage and Administration

Lidocaine enter n / a, IM, IV.

Forlocal conduction anesthesia The usual dose is from 5 ml to 10 ml of a 2% solution of lidocaine. Foranesthesia of the brachial and sacral plexus enter 5-10 ml of 2% solution.

Forfinger anesthesia apply from 2 ml to 3 ml of 2% solution. The maximum dose of a 2% Lidocaine solution is 10 ml, this dose should not be re-administered within 24 hours. With local anesthesia, the drug should be injected into highly vascularized tissues carefully to avoid getting into the bloodstream. Before the introduction of lidocaine in high doses, the appointment of barbiturates is recommended.

When applied incardiology administered IV, a single dose of 1-2 mg / kg of body weight and can be up to 100 mg. This dose can be re-administered every 3-4 minutes to a total dose of 300 mg.

IV the drip is administered at a dose of 20-55 mg / kg / min, but not more than 2 mg / min in isotonic or in Ringer's solution. To / in the drip introduction go only after the jet. Duration IV drip is 24-36 hours.

IM is administered in a dose of 2-4 mg / kg of body weight in the gluteal or deltoid muscle at intervals of from 4 hours to 6 hours. A single dose should not exceed 200 mg.

Withmyocardial infarction Before transporting the patient to the hospital, Lidocaine is injected intramuscularly at a dose of 4 mg / kg as a single prophylactic dose (from 200 to 300 mg maximum).

With the help of a soaked tampon, the drug can be applied to large surfaces.
Children under 2 years old It is preferable to use the preparation by applying a tampon, which allows you to avoid the fear that appears during spraying, as well as the burning sensation.

For patients with hepatic and / or heart failure A dose reduction of 40% is recommended.

When using an aerosol cylinder should be kept upright.

Adverse reactions

From the side of the central nervous system: possible headaches, dizziness, drowsiness, anxiety, euphoria, tinnitus, numbness of the tongue and oral mucosa, speech and vision problems.

Since the cardiovascular system: at higher doses arterial hypotension, collapse, bradycardia, conduction disorders are possible.

Allergic reactions: rarely - rash, itching, exfoliative dermatitis, anaphylactic shock, hyperthermia.

Local reactions: feeling of light burning, which disappears as the anesthetic effect develops (within 1 min).

Contraindications

  • weakness of the sinus node in elderly patients,
  • intracardiac block II-III degree except when a probe is inserted to stimulate the ventricles),
  • pronounced bradycardia,
  • cardiogenic shock, t
  • severe liver function disorder,
  • increased individual sensitivity to lidocaine hydrochloride.

Drug interactions

It is undesirable to combine lidocaine with the following drugs:

With beta-blockers due to the enhanced toxic properties of lidocaine, with digitoxin - due to a weakening of the cardiotonic effect, with curariform drugs - muscle relaxation increases.

It is unreasonable to prescribe lidocaine together with aymalin, amiodarone, verapamil or quinidine due to increased cardio-depressive action.

The combined use of lidocaine and procainamide can cause excitation of the central nervous system, hallucinations.

With intravenous administration of hexenal or thiopental sodium, against the background of the action of lidocaine, respiratory depression is possible.

Under the influence of MAO inhibitions, the local anesthetic action of lidocaine is likely to increase. Patients taking MAO inhibitors should not be given lidocaine parenterally.

With the simultaneous appointment of lidocaine and polymyxin-B may increase the inhibitory effect on the neuromuscular transmission, so in this case it is necessary to monitor the respiratory function of the patient.

With simultaneous use of lidocaine with sleeping pills or sedatives, it is possible to increase their inhibitory effect on the central nervous system.Intravenous administration of lidocaine to patients taking cimetidine may have undesirable effects such as stupor, drowsiness, bradycardia, parasthesia, etc. inactivation in the liver. If necessary, the combination therapy with these drugs should reduce the dose of lidocaine.

Pharmaceutical Interaction
With simultaneous use of the following drugs increase the concentration of lidocaine in the blood serum: aminazine, cimetidine, propranolol, pethidine, bupivacaine, quinidine, disopyramide, amitriptyline, imipramine, nortriptyline.

Pregnancy and Lactation

During pregnancy and breastfeeding is possible if the expected effect of therapy outweighs the potential risk to the fetus and child.

Special instructions

It is used with caution in patients with impaired liver function, circulatory failure, arterial hypotension, renal insufficiency, epilepsy. In these cases, a reduction in the dose of the drug is required.

With rapid intravenous administration, a sharp decrease in blood pressure and the development of collapse can occur.

In these cases, mezaton, ephedrine and other vasoconstrictor agents are used. Lidocaine solutions should be gently injected into highly vascularized tissues to prevent the drug from getting into the vessel lumen (for example, in the neck area during thyroid surgery) (in such cases, smaller doses of lidocaine are shown.

With extreme caution should use the drug in the presence of injuries of the mucous membranes, with mental retardation, as well as very old and / or weakened patients who are already receiving drugs such as lidocaine for cardiac problems.

In dentistry and orthopedics, the drug should be used only with elastic impression materials.
Avoid contact with the aerosol or contact with eyes; it is important to prevent the aerosol from entering the respiratory tract (risk of aspiration). Applying the drug on the back of the pharynx requires special care. It should be remembered that lidocaine suppresses the pharyngeal reflex and inhibits the cough reflex, which can lead to aspiration, bronchopneumonia.

Use in Pediatrics
It should be borne in mind that in children the swallowing reflex occurs much more frequently than in adults.
Lidocaine aerosol is not recommended for local anesthesia before tonsillectomy and adenotomy inchildren under the age of 8 years.

Influence on ability to drive motor transport and control mechanisms
If the side effects after the use of the drug do not cause discomfort, there are no restrictions for driving vehicles and controlling mechanisms.

Overdosage

Symptoms: initial signs of intoxication - dizziness, nausea, vomiting, euphoria, asthenia, low blood pressure; then - convulsions of the facial muscles of the face, tonic-clonic convulsions of skeletal muscles, psychomotor agitation, bradycardia, collapse; when used in childbirth in a newborn - bradycardia, depression of the respiratory center, respiratory arrest.

Treatment: when the first signs of intoxication appear, the administration is stopped, the patient is transferred to the horizontal position; prescribe inhalation of oxygen. When convulsions - intravenous 10 mg of diazepam. In bradycardia, m-anticholinergics (atropine), vasoconstrictors (norepinephrine, phenylephrine). Intubation, mechanical ventilation and resuscitation are possible. Dialysis is ineffective.

  • Brand name: Lidocaine
  • Active ingredient: Lidocaine
  • Dosage form: Injection.
  • Manufacturer: Moskhimpharmpreparaty
  • Country of Origin: Russia

Studies and clinical trials of Lidocaine (Click to expand)

  1. Evaluation of topical anesthetics by laser-induced sensation: Comparison of EMLA 5% cream and 40% lidocaine in an acid mantle ointment
  2. An electrophysiological analysis of the protective effects of felbamate, lamotrigine, and lidocaine on the functional recovery from in vitro ischemia in rat neocortical slices
  3. Drug-induced vasodilation: In vitro and in vivo study on the effects of lidocaine and papaverine on rabbit carotid artery
  4. REGIONAL DISTRIBUTION OF 11C-LABELED LIDOCAINE, BUPIVACAINE, AND ROPIVACAINE IN THE HEART, LUNGS, AND SKELETAL MUSCLE OF PIGS STUDIED WITH POSITRON EMISSION TOMOGRAPHY
  5. Effects of intravenous lipid as a source of energy in parenteral nutrition associated hepatic dysfunction and lidocaine elimination: a study using isolated rat liver perfusion
  6. Development and Validation of a High-performance Liquid Chromatography Method for the Determination of Cocaine, its Metabolites and Lidocaine
  7. Kinetics and rat locomotor activity following cocaine and lidocaine administration
  8. Chromatographic behavior of underivatized lidocaine and metabolites in CGC
  9. Characterization of lidocaine and its metabolites in human plasma using capillary electrophoresis
  10. Potentiation of differential hyperthermic sensitivity of AKR leukemia and normal bone marrow cells by lidocaine or thiopental
  11. Lidocaine cystometry in the diagnosis of bladder overactivity
  12. Simultaneous Determination of Tramadol and Lidocaine in Urine by End-column Capillary Electrophoresis with Electrochemiluminescence Detection
  13. Separation of lidocaine and its metabolites by capillary electrophoresis using volatile aqueous and nonaqueous electrolyte systems
  14. Topical lidocaine gel relieves postherpetic neuralgia
  15. Lidocaine release from polycaprolactone threads
  16. Synthesis and Pharmacological Properties of Three Lidocaine Cyclovinylogues
  17. Tolperisone: Evaluation of the Lidocaine-Like Activity by Molecular Modeling
  18. Arthroscopy in septic arthritis. Lidocaine- and iodine-containing contrast media are bacteriostatic
  19. A comparison of intravenous and subarachnoid lidocaine pharmacokinetics in the rhesus monkey
  20. Protein binding of lidocaine in canine serum and plasma: Effects of an acidic pH and the technique of study
  21. First-pass elimination of lidocaine in the rabbit after peroral and rectal route of administration
  22. Meta-analysis of intravenous lidocaine and postoperative recovery after abdominal surgery
  23. Validation and application of capillary electrophoresis for the analysis of lidocaine in a skin tape stripping study
  24. Direct (non-chromatographic) quantification of drugs and their metabolites from human plasma utilizing chemical lonization mass spectrometry and stable isotope labeling: Quinidine and lidocaine

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