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Allergoferon [Interferon Alfa-2b, Loratadine]

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2019-09-19
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Clinical Pharmacology

A drug Grippferon with loratadine created on the basis of recombinant human interferon alpha-2b and the second generation antihistamine substance - loratadine.

It is well known that in patients with allergic diseases, in particular with allergic rhinitis, there is an increased susceptibility to respiratory viral infections. Inflammatory changes in the mucous membrane of the respiratory tract of patients with allergic rhinitis contribute to the reduction of antiviral and antimicrobial protection and inhibition of local immunity. As a result, a favorable environment for the reproduction of respiratory viruses is created. Numerous clinical observations and laboratory studies indicate the association of respiratory infection with exacerbation of allergies.

The research center FIRN M pays great attention to this area and continues work on “creating combination drugs that provide both antiviral and antiallergic therapy or the combined use of traditional antiallergic components and interferon drugs” (P.Ya. Gaponyuk, 2008).

Significant long-term experience of effective use of Grippferon, nasal and spray drops for the prevention and treatment of influenza and ARVI in adults and children since birth, as well as the successful experience of using Allerhoferon-gel for the treatment of allergic rhinitis and conjunctivitis was taken into account when developing a new combination drug - nasal ointment Grippferon with loratadine.

Grippferon ointment with loratadine It has an immunomodulatory, antiviral and antihistamine effect, reduces capillary permeability and prevents the development of edema of the nasal mucosa.

Successful clinical trials of Grippferon with loratadine in the leading scientific and clinical centers of the Russian Federation allow us to recommend the drug for use in general medical practice.

Indications

Grippferon with loratadine is available as a nasal ointment and is intended for the prevention and treatment of influenza and acute respiratory viral infections as part of complex therapy in adults, including patients with allergic rhinitis.

Interferon Alfa-2b, Loratadine is marketed under different brands and generic names, and comes in different dosage forms:

Brand nameManufacturerCountryDosage form
gel
Grippferon Firn M Russia ointment

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Allergoferon [Interferon Alfa-2b, Loratadine]

Dosage and Administration

For the prevention of influenza and SARS (after contact with the sick) the drug is used 1 time per day (in the morning), lubricating the nasal mucosa, releasing 1 cm of the drug in each nasal passage for 7 days.

For the treatment of influenza and SARS the drug is used 5 times a day, lubricating the nasal mucosa, releasing 1 cm of the drug in each nasal passage for 7 days.

Before applying the ointment, it is necessary to clean the nasal cavity, and after application - to massage the wings of the nose for a better distribution of the ointment over the surface of the nasal mucosa. After application, it is possible to sneeze, itch, temporary disturbance of smell.

Adverse reactions

Perhaps sneezing, itching at the site of application, a temporary violation of the smell.

Contraindications

  • hypersensitivity to interferon alpha-2b, loratadine or other components of the drug;
  • children's age up to 18 years (due to the lack of data on the efficacy and safety of the drug in children);
  • pregnancy, breastfeeding period.
  • Brand name: Allerhoferon
  • Active ingredient: Interferon Alfa-2b, Loratadine
  • Manufacturer: Meda Pharma GmbH & Co. KG

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