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Tiocetam belongs to the group of cerebroactive agents, exhibits nootropic anti-ischemic and antioxidant properties. The pharmacological effect of the drug is due to the mutually potentiating effect of Thiotriazoline iipyracetam. Piracetam is a cyclic derivative of GABA, a nootropic agent; It acts directly on the brain, improving functions such as learning, memory, attention and consciousness, without a sedative or psychostimulating effect. At the neuronal level, piracetam facilitates various types of synaptic transmission, having a predominant effect on the density and activity of postsynaptic receptors. The hemorheological effects of piracetam are associated with its effect on red blood cells, platelets, and vascular wall. Thiotriazoline reacts with reactive oxygen species and lipid radicals due to the pronounced reducing properties of the thiol group and prevents the occurrence of reactive oxygen species by reactivating antiradical enzymes: superoxide dismutase, catalase and glutathione peroxidase.
Tiocetam improves the integrative and cognitive activity of the brain, promotes the learning process, eliminates amnesia, improves the performance of short-term and long-term memory.
- Chronic cerebral ischemia.
- The recovery period of ischemic stroke (including in patients with non-elemental cognitive impairment).
- Diabetic encephalopathy.
1 ml of solution contains:
active substances: Thiotriazoline 25 mg, piracetam 100 mg
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Dosage and Administration
The drug is administered intravenously, intramuscularly only when it is impossible to ingest.
In chronic disorders of cerebral circulation and in the recovery period after an ischemic stroke, 20-30 ml of the drug, previously diluted in 100-150 ml of 0.9% sodium chloride solution, are prescribed and injected intravenously 1 time per day. The course of treatment is 2 weeks, in the future, switch to tablet form.
In diabetic encephalopathy, 5 ml ip is prescribed 1 time / day for 10 days with the further prescription of the tablet form.
Nervous system disorders: motor disinhibition, irritability, drowsiness, depression, asthenia, headache, dizziness, tinnitus, insomnia, mental agitation, imbalance, ataxia, exacerbation of the course of epilepsy, anxiety, hallucinations, confusion.
On the part of the gastrointestinal tract: nausea, vomiting, diarrhea, pain in the abdomen (including gastralgia) and bloating, dry mouth.
Since the cardiovascular system: tachycardia, increased blood pressure, pain in the heart, arrhythmias, in elderly people may exacerbate coronary insufficiency.
Allergic reactions: hypersensitivity, anaphylactic reactions, including dermatitis, pruritus, urticaria, and angioedema, fever.
On the part of the respiratory system: shortness of breath, asthma.
On the part of metabolism: an increase in body weight.
On the part of the hearing: vertigo.
- Hypersensitivity to piracetam or thiotriazoline, as well as to other components of the drug.
- Chorea Huntington.
- Acute violation of cerebral circulation (hemorrhagic stroke).
- Severe chronic renal failure (creatinine clearance less than 20 ml / min).
- Psychomotor agitation at the time of the appointment of the drug.
- Pregnancy and lactation.
- Hereditary lactose intolerance.
- Lactase deficiency.
- Deficiency of sucrase / isomaltase.
- Fructose intolerance.
- Glucose-galactose malabsorption.
Thiocetam can not be simultaneously administered with drugs that have an acidic pH value. Due to the presence of piracetam, the effect of antidepressants and antianginal drugs is enhanced. With simultaneous appointment with thyroid hormones, confusion, irritability and sleep disturbance are possible.
Piracetam does not inhibit the cytochrome P450 isoenzymes. Metabolic interaction with other drugs unlikely
Co-administration with alcohol did not affect the level of serum piracetam concentration; the concentration of ethanol in the serum did not change when taking 1.6 g of piracetam.
Pregnancy and Lactation
The experience of using the drug during pregnancy or breastfeeding is absent, so the drug should not be prescribed for this category of women.
Experience in the use of the drug for the treatment of children is not, therefore, the drug is contraindicated for the treatment of children under 18 years.
With long-term therapy in elderly patients, regular monitoring of renal function is recommended, and if necessary, dose adjustment is carried out depending on creatinine clearance.
Influence on the ability to drive vehicles and the management of machines and mechanisms
During the period of treatment, it is necessary to refrain from driving vehicles and practicing potentially hazardous activities that require increased concentration and psychomotor speed of reaction (driving a car, etc.).
Symptoms: the occurrence or increase in the severity of dose-dependent side effects of the drug.
Treatment: removal of the drug, induction of vomiting, gastric lavage, symptomatic therapy.
- Brand name: Tiocetam
- Active ingredient: Piracetam, Thiotriazoline
- Dosage form: Injection
- Manufacturer: Halychfarm
- Country of Origin: Ukraine