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Pyridoxine hydrochloride - vitamin B6. Phosphorylated and in the form of pyridoxal phosphate is part of the enzymes catalyzing decarboxylation and transamination. It plays an important role in the metabolism of tryptophan, glutamic acid, cysteine, methionine, as well as in the transport of amino acids across the cell membrane. Necessary for the activation of phosphorylase, for the formation of neurotransmitters, gamma-aminobutyric acid, glycine, serotonin. Participates in the exchange of vitamin B12, folic acid, in the synthesis of porphyrins, in the exchange of unsaturated fatty acids. It is used to activate metabolic processes in myofibrils, especially during myocardial hypoxia. The daily need for adults is 2–2,5 mg, for children from 6 months to 1 year - 0.5 mg, 1–1.5 years - 0.9 mg, 1.5–2 years - 1 mg, 3– 4 years - 1.3 mg, 5–6 years - 1.4 mg, 7–10 years - 1.7 mg, 11–13 years - 2 mg, for boys of 14–17 years - 2.2 mg, for girls 14-17 years old - 1.9 mg.
B6-hypovitaminosis, toxemia of pregnant women, sideroblastic anemia, leukopenia, CNS diseases (parkinsony, small chorea, Littl's disease, radiculitis, neuritis, neuralgia, Meniere's disease), sea and airborne diseases, atherosclerosis, diabetes, seborrheic-like and non-seboric, non-seborrheic and non-seborrheic diseases, atherosclerosis, diabetes, seborrhea-like and non-seborrheic diseases , neurodermatitis, psoriasis, exudative diathesis, use of isoniazid preparations.
1 vial (1 ml) contains: pyridoxine hydrochloride 50 mg, water for injection up to 1 ml.
Pyridoxine is marketed under different brands and generic names, and comes in different dosage forms:
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|Pyridoxine hydrochloride pills||Ozon||Russia||pills|
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Dosage and Administration
Inside, after eating.
For the prevention of B6-hypovitaminosis prescribed to adults for 0,002 - 0,005 g per day, children - for 0,002 g per day.
Therapeutic doses for oral administration are for adults 0.02 - 0.03 g 1 - 2 times a day; for children, reduce the dose according to age. The course of treatment is 1 - 2 months.
Allergic reactions, increased acidity of gastric juice.
Hypersensitivity. With care: a peptic ulcer of a stomach and duodenum.
The effect of reducing isoniazid, cycloserine, penicillamine. Pharmaceutical is not compatible with vitamins B1 and B12. Weakens anti-parkinsonian activity of levodopa.
- Active ingredient: Pyridoxine
- A novel mutation of the erythroid-specific ?-aminolevulinate synthase gene in a patient with non-inherited pyridoxine-responsive sideroblastic anemia
- Monitoring Pyridoxine by Capillary Zone Electrophoresis with Electrochemical Detection
- Lipase-Catalyzed Acylation and Deacylation Reactions of Pyridoxine, a Member of Vitamin-B6 Group
- Clinical and biochemical studies of pyridoxine deficiency in patients with neoplastic diseases
- Effect of thiamine hydrochloride, pyridoxine hydrochloride and calcium-d-pantothenate on the patulin content of apple juice concentrate
- Pipecolic acid elevation in plasma and cerebrospinal fluid of two patients with pyridoxine-dependent epilepsy
- Pyridoxine responsive hereditary sideroblastic erythropoiesis and iron overload: Two microcytic subpopulations in the affected male, one normocytic and one microcytic subpopulation in the obligate female carrier
- Pyridoxine-unresponsive homocystinuria with an unusual clinical course
- Functional COMT variant predicts response to high dose pyridoxine in Parkinson's disease
- In vivo gene therapy for pyridoxine-induced neuropathy by herpes simplex virus-mediated gene transfer of neurotrophin-3
- Pipecolic acid: A diagnostic marker in pyridoxine-dependent epilepsy
- Folinic acid–responsive seizures are identical to pyridoxine-dependent epilepsy
- Pyridoxine-dependency seizure: Report of a rare presentation
- Late-onset pyridoxine-dependency convulsions
- Biochemical studies of pyridoxal and pyridoxal phosphate status and therapeutic trial of pyridoxine in patients with carpal tunnel syndrome
- Atypical presentations of pyridoxine-dependent seizures: A treatable cause of intractable epilepsy in infants
- Urinary excretion of pyridoxine and 4-pyridoxic acid in rheumatoid arthritis
- Simultaneous determination of nicotinamide, pyridoxine hydrochloride, thiamine mononitrate and riboflavin in multivitamin with minerals tablets by reversed-phase ion-pair high performance liquid chromatography
- Synthesis of a Pyridoxine–Peptide Based Delivery System for Nucleotides
- ChemInform Abstract: Chemistry of 1,3-Dioxepins. Part 11. Bis-(4,7-dihydro-1,3-dioxepin) Approach to Pyridoxine Intermediates: 1,5-Dihydro-8-methyl-3H-(1,3) dioxepino(5,6-c)pyridin-9-ols.
- ChemInform Abstract: Photogeneration of an o-Quinone Methide from Pyridoxine (Vitamin B6) in Aqueous Solution.
- ChemInform Abstract: Lipase-Catalyzed Acylation and Deacylation Reactions of Pyridoxine, a Member of Vitamin-B6 Group.
- ChemInform Abstract: Pyridoxine as a Substrate for Screening Synthetic Potential of Glycosidases.
- Pyridoxine as a Template for the Design of Antiplatelet Agents.