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Thioctic acid

Canonpharma
759 Items
2019-09-19
Dosage form
Brand & Manufacturer
Package Size
$19.75
Quantity
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Clinical Pharmacology

Thioctic acid (alpha-lipoic acid) - an endogenous antioxidant (binds free radicals), is formed in the body during the oxidative decarboxylation of alpha keto acids. As a coenzyme, mitochondrial multienzyme complexes are involved in the oxidative decarboxylation of pyruvic acid and alpha-keto acids.
By the nature of the biochemical action is similar to the B vitamins. It has a hepatoprotective, hypolipidemic, hypocholesterolemic, hypoglycemic effect. Helps reduce blood glucose and increase glycogen content in the liver, as well as reduce insulin resistance.
Participates in the regulation of lipid and carbohydrate metabolism, stimulates the exchange of cholesterol, improves liver function. Improves trophism of neurons. The use of the megoulamine salt of thioctic acid (which has a neutral reaction) makes it possible to reduce the severity of side reactions.

Pharmacokinetics

The time to reach maximum concentration is 10-11 minutes. The area under the concentration-time curve is about 5 μg × h / ml.
Bioavailability - 30%. It has the effect of "first pass" through the liver. Metabolized in the liver by side chain oxidation and conjugation. The volume of distribution is about 450 ml / kg. Total plasma clearance - 10-15 ml / min. Thioctic acid and its metabolites are excreted by the kidneys (80-90%). The half-life is 20-50 minutes.

Indications

Diabetic and alcoholic neuropathy.

Composition

1 ml of solution contains:

Active substance: thioctic acid (alpha lipoic acid) 12.00 mg;

Excipients: meglumine (N-methyl-D-glucamine), macrogol (polyethylene glycol 400), povidone (collidon® 17 РF or plasdon C-15), water for injection.

Thioctic acid is marketed under different brands and generic names, and comes in different dosage forms:

Brand nameManufacturerCountryDosage form
Tiolepta Canonpharma Russia solution
Espa-lipon Esparma Germany ampoules
Thiolipon Biosynthesis Russia pills
Octolipen Pharmstandard Russia pills
Berlition Berlin-Chemie/Menarini Germany ampoules
Tiolepta Canonpharma Russia pills
Thioctacid BV Meda Pharma GmbH & Co. KG Switzerland pills

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Thioctic acid

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